Anti-Pyretic Activity of two Varieties of Hibiscus Rosa Sinensis L.

Hibiscus rosa-sinensis has been traditionally used by local communities to treat fever. However, there are only limited data have published support the antipyretic effects. The objective of this study is investigate properties and possible mechanism ethanol extracts rosa-sinensisL. (red colored flower) rosa-sinensisvar. Alba (white flower). Phytochemical analysis, heavy metals screening acute toxicity test were done evaluate safety extracts. first model ran induced fever in rats injecting Brewer's Yeast subcutaneously then treated with 4 at dosage 5 & 50 mg/kg. dosages for obtained test. Ibuprofen was as a reference drug, dose 100 Temperatures measured using digital thermometer. results expressed mean ± S.E.M. analyzed SAS system. showed that white flower extract 5mg/kg mg/kg significantly (p <0.05) reduced total temperature when compared positive control group. Therefore, research suggests probability its therapeutic effectiveness plant-based agent claimed traditional medicine practitioners.